People

Lena Tveriakhina

Group leader

Lena received her B.Sc and M.Sc from Heinrich-Heine University in Duesseldorf. For her doctoral work she moved to Hannover Medical School and under supervision of Achim Gossler she characterized the functional diversity of the Notch ligands DLL1 and DLL4 in the mouse model. After a short postdoc in the Gossler lab studying the molecular, biochemical, and functional analysis of FOXJ1 targets in murine motile cilia she joined the laboratory of Stephen C. Blacklow at Harvard Medical School. As a postdoc in the Blacklow lab she focused on visualizing Notch signaling dynamics in living cells using advanced imaging techniques. Since October 2024 she is a junior group leader at University of Osnabrueck in Germany leading the Multicellular Signaling Dynamics Group studying how the dynamics of signaling regulates cell fate decisions in multicellular systems.

Yannik Sander, M.Sc.

PhD Student

Yannik obtained his B.Sc. in Plant Physiology from the University of Osnabrück, where he investigated cotranslational protein degradation in plants using a ubiquitin-based reporter system. He then pursued an M.Sc. in Molecular Cell Biophysics at the same institution, specializing in biophysics, cell biology, and advanced microscopy. Fascinated by the interplay between cellular processes and imaging techniques, he investigated Gasdermin E–mediated cell death in cancer cells for his thesis.

In March 2025, he started his Ph.D. in the Multicellular Signaling Dynamics Group at the University of Osnabrück. His current research explores how endocytosis, membrane trafficking, and lipid dynamics regulate Notch signaling, integrating advanced microscopy and molecular engineering to dissect receptor–ligand communication in multicellular systems.

Marie Bleitner, B.Sc.

Master Student

Marie completed her B.Sc. in Animal Physiology at the University of Osnabrück, focusing on stem cell and regeneration research in Schmidtea mediterranea. In her work, she characterized the effects of gene knockdowns on the regenerative abilities of planarians using qPCR and in situ hybridization. Now she is working on her master’s project in the Tveriakhina Lab. Her work focuses on designing and cloning vector constructs for recombinant Notch ligands, expressing and purifying these proteins in mammalian cells, and generating Supported Lipid Bilayers to which the purified ligands can be anchored. The goal of her project is to establish a robust experimental system that can be used to study Notch synapses under defined and controllable conditions.

Marina Poegel, B.Sc.

Master Student

Marina completed her B.Sc. in Neurobiology at the University of Osnabrück, investigating the Survival of Motor Neuron (SMN) protein, which is important in Spinal Muscular Atrophy. In her work, she studied the influence of overexpressed exogenous SMN protein on the morphology of PC12 cells, especially the formation and length growth of cell processes. After finishing her research internship in the Tveriakhina Lab, she started working on her master‘s project focusing on hepatic organoids as a model system. The goal of her project is to further characterize the development of hepatic organoids in order to investigate how alterations in the Notch signaling pathway affect their gene expression and morphology. To achieve this, she is using both histological sectioning and qPCR analysis.

Carlotta Hakemann, B.Sc.

Master Student

Carlotta completed her B.Sc. in evolutional biologie at the technical University of Braunschweig, investigating the heat tolerance of Xenopus laevis, the african clawed frog, under laboratory conditions. For the Master program, she moved to Osnabrück to pursue her master‘s degree with a focus on molecular cell biology at the Univerity of Osnabrück and in March 2026 she started her master´s project in the Tveriakhina Lab. She is generating differend knock-in lines of iPSCs. Additionally she will investigate the development of intestinal organoids using the new cell lines with regards to the Notch and Wnt signaling Pathway.

You?

Research Internship, Bachelor or Master Thesis?

Alumni:

  • Dina Dell (Bachelor thesis student)
  • Lea Sophie Pole (Lab rotation)
  • Rieke Exner (Lab rotation)